Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence
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چکیده
منابع مشابه
Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms.
OBJECTIVE Several clinical studies suggest that black cohosh may be effective in climacteric complaints. However, evidence of its efficacy based on current quality standards has been limited. METHODS This randomized, multicenter, double-blind clinical trial compared the efficacy and tolerability of the isopropanolic black cohosh extract in the treatment of climacteric complaints compared with...
متن کاملEfficacy and Safety of Isopropanolic Black Cohosh Extract for Climacteric Symptoms
METHODS: This randomized, multicenter, double-blind clinical trial compared the efficacy and tolerability of the isopropanolic black cohosh extract in the treatment of climacteric complaints compared with placebo. A total of 304 patients were randomly allocated to receive tablets corresponding to 40mg drug ormatching placebo daily for 12 weeks. The primary efficacy measure was the change from b...
متن کاملCommentary on black cohosh for the treatment of menopausal symptoms.
Black cohosh has central opioid activity in postmenopausal women: evidence from naloxone blockade and positron emission tomography neuroimaging. Abstract To test whether black cohosh (BC) exhibits an action on the central endogenous opioid system in postmenopausal women. This was a mechanistic study conducted in the same individuals of luteinizing hormone pulsatility with a saline/naloxone chal...
متن کاملEfficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone.
OBJECTIVE To investigate the efficacy-safety balance of the isopropanolic extract of Actaea (=Cimicifuga) racemosa (iCR, Remifemin) in comparison with tibolone in Chinese women with climacteric complaints. METHOD The randomized, double-blind, controlled 3-month study in 5 centers of 3 cities in China enrolled 244 menopausal patients aged 40-60 years and with a Kupperman Menopause Index (KMI)>...
متن کاملInhibitory effect of an isopropanolic extract of black cohosh on the invasiveness of MDA-mB 231 human breast cancer cells.
BACKGROUND The isopropanolic extract of black cohosh (iCR)b has recently been reported to exert antiproliferative and apoptosis-inducing effects on estrogen receptor-positive MCF-7, as well as estrogen receptor-negative MDA-MB 231 human breast cancer cells. To broaden observations, the anti-invasive effects of iCR and its two major fractions triterpene glycosides (TTG) and cinnamic acid esters ...
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ژورنال
عنوان ژورنال: Climacteric
سال: 2020
ISSN: 1369-7137,1473-0804
DOI: 10.1080/13697137.2020.1820477